| 產(chǎn)品詳情 |
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| Antigenic Specificity | Wiskott-Aldrich Syndrome-Like (WASL) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dynamics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4, 5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac (reviewed in 1). Both WASP and WAVE functions appear to be essential, as knockout of either N-WASP or Scar-2 in mice results in cardiac and neuronal defects and embryonic lethality. Loss of WASP results in immune system defects and fewer immune cells. WAVE-2 (WASF2) is widely distributed, while WAVE-1 and WAVE-3 are strongly expressed in brain. WAVE-3 may act as a tumor suppressor in neuroblastoma, a childhood disease of the sympathetic nervous system. Increased expression of WAVE-3 is seen in breast cancer, and studies in breast adenocarcinoma cells indicate that WAVE-3 regulates breast cancer progression, invasion and metastasis through the p38 mitogen-activated protein kinase (MAPK) pathway.Synonyms: WAS, IMD2, THC, THC1, WASP |
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| Immunogen | Recombinant protein of human WAS |
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| Other Names | wasl|zgc:55478|zgc:77237|n-wasp|nwasp|WASL|IMD2|SCNX|THC|THC1|WASP|U42471|Wasp|N-WASP|NWASP|TRS4|2900021I12Rik|3110031I02Rik |
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| Gene, Accession # | Gene ID: 7454,22376,317371 |
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| Catalog # | ABIN1513688 |
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| Price | |
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| Order / More Info | Wiskott-Aldrich Syndrome-Like (WASL) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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