| 產(chǎn)品詳情 |
| Edit |   |
| Antigenic Specificity | PD-1 |
| Clone | 7A11B1 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | purified |
| Size | 100 μg |
| Concentration | n/a |
| Applications | Immunocytochemistry: 20 μg/mL, Immunofluorescence: 20 μg/mL, Immunohistochemistry: 2.5 μg/mL, Western Blot: 1 μg/mL |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PD-1 Monoclonal Antibody (7A11B1). Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of ``danger signals'' such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and |
| Immunogen | n/a |
| Other Names | CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, programmed cell death protein 1, protein PD-1 |
| Gene, Accession # | Entrez: 18566, 301626, 5133; Uniprot: Q02242, Q15116 |
| Catalog # | MA5-15780 |
| Price | |
| Order / More Info | PD-1 Antibody from INVITROGEN ANTIBODIES |
| Product Specific References | PubMed: 28196545 |
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