| 產(chǎn)品詳情 |
| Edit |   |
| Antigenic Specificity | PD-1 |
| Clone | J43 |
| Host Species | Armenian Hamster |
| Reactive Species | mouse |
| Isotype | IgG |
| Format | purified |
| Size | 250 ug |
| Concentration | n/a |
| Applications | Flow Cytometry: 2.0 μg/1x10^6 cells |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PD-1 Monoclonal Antibody (J43). Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of ``danger signals'' such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and au |
| Immunogen | n/a |
| Other Names | CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, programmed cell death protein 1, protein PD-1 |
| Gene, Accession # | Entrez: 18566; Uniprot: Q02242 |
| Catalog # | PA5-35008 |
| Price | |
| Order / More Info | PD-1 Antibody from INVITROGEN ANTIBODIES |
| Product Specific References | PubMed: 24633065, 25614821, 26378075, 26466956, 28066430, 28124096, 28402334 |
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