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產品名稱

Recombinant Human sRANK Ligand from AGRENVEC

產品貨號

RF0038

產品價格

現(xiàn)貨詢價，電話：010-67529703

產品規(guī)格

1 μg, 10 μg, 50 μg, 100 μg, 250 μg

產品品牌

AGRENVEC

產品概述

產品詳情

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Product Name	Recombinant Human sRANK Ligand
Description	Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. Recombinant human RANKL is a member of TNF super family, a cytokine that play a central role in bone remodeling and disorders of mineral metabolism. It was shown to be a dendritic cell survival factor, T-cell activator and osteoclast regulator because RANKL mediates the osteoclast differentiation, survival and activation. Native RANKL is a type II trans-membrane protein with an extracellular binding domain that interacts with RANK and OPG receptors. OPG protects the skeleton from excessive bone resorption by binding to RANKL and preventing it from binding to its receptor, RANK. Thus, RANKL/OPG ratio became an important determinant of bone mass and skeletal integrity. In addition, this protein was shown to activate anti-apoptotic kinase AKT/PKB through a signalling complex involving SRC kinase and tumour necrosis factor receptor-associated factor (TREAF). Recent findings shown that OPG/RANK/RANKL system has been identifies as a possible mediator of arterial calcification suggesting common links between osteoporosis and vascular diseases. Recombinant human sRANKL is a glycosylated polypeptide chain containing 175 amino acids (70 - 244 aa of O14788 TNF11_HUMAN) and a His-tag at the N-terminal end. It has a predicted molecular mass of 21.1 kDa, however as result of glycosylation, the recombinant protein could migrate as two bands with an apparent molecular mass of 21-23 kDa in SDSPAGE. Purity >97% by SDS-PAGE gel
Size	1 μg, 10 μg, 50 μg, 100 μg, 250 μg
Concentration	n/a
Applications	SDS-PAGE, Western Blot, Antibody Production.
Other Names	TNFSF11, OPGL, TRANCE
Gene, Accession, CAS #	UniProt: O14788
Catalog #	RF0038
Price
Order / More Info	Recombinant Human sRANK Ligand from AGRENVEC
Product Specific References	- Anderson, D. et al.,1997. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390: 175-179 - Takahashi, N. et al., 1999. A new member of tumour necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function. Biochem Biophys. Res. Common. Mar 24; 256(3):449-55. - Yasuda, H. et al., 1998. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA 95:3597-3602. - D'Amelio, P. et al., 2009. The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease.J Endocrinol Invest. 32(4 Suppl):6-9. - Suda, T. et al., 1999. Modulation of osteoclast differentiation and function by de the new members of the tumour necrosis factor receptor and ligand family. Endocr. Rev.20:345-350.
產品資料

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