| 產(chǎn)品詳情 |
| Edit |   |
| Antigenic Specificity | FOXP3 |
| Clone | 22510 |
| Host Species | Mouse |
| Reactive Species | human, rat |
| Isotype | IgG1 |
| Format | purified |
| Size | 100 μg |
| Concentration | n/a |
| Applications | Immunocytochemistry: 1:1000, Immunofluorescence: 1:1000, Immunohistochemistry (Paraffin): 10 μg/mL, Western Blot: 1 μg/mL |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | FOXP3 Monoclonal Antibody (22510). FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also |
| Immunogen | n/a |
| Other Names | JM2, AIID, DIETER, IPEX, MGC141961, MGC141963, PIDX, XPID, FOXP3delta7; forkhead box protein P3; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; scurfin |
| Gene, Accession # | Entrez: 317382, 50943; Uniprot: Q9BZS1 |
| Catalog # | MA5-14664 |
| Price | |
| Order / More Info | FOXP3 Antibody from INVITROGEN ANTIBODIES |
| Product Specific References | n/a |
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