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| Antigenic Specificity | FOXP3 |
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| Clone | 259D |
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| Host Species | Mouse |
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| Reactive Species | human, cross-reactivity: cynomolgus, rhesus, baboon, chimpanzee |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 25 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), IHC, Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human FOXP3. FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 259D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235. |
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| Immunogen | Full-length FOXP3 protein |
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| Other Names | Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2 |
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| Gene, Accession # | Gene ID: 50943 |
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| Catalog # | 320201 |
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| Price | |
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| Order / More Info | FOXP3 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 16403912,16617117,16732291,17644734,18313267,18981295,19180473,19875613,24610777,24943216,24947990 |
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