| 產(chǎn)品詳情 |
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| Antigenic Specificity | CENTG1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 10 μg/mL, Western Blot: 0.5-2 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CENTG1 Polyclonal Antibody. Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity. PIKE exists in multiple isoforms; a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin -gamma 1. The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits th |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 116986, 216439; Uniprot: Q3UHD9, Q99490 |
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| Catalog # | PA5-20065 |
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| Price | |
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| Order / More Info | CENTG1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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