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| Antigenic Specificity | Neurofilament Marker |
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| Clone | SMI 312 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1/ IgM |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | IHC-P, Western Blot (WB), ICC, Immunofluorescence Microscopy (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Neurofilament Marker (pan axonal, cocktail). Neurofilaments (NF) are approximately 10 nanometer intermediate filaments found in neurons. They are a major component of the neuronal cytoskeleton and their function is primarily to provide structural support for the axon and to regulate axon diameter. There are three major NF subunits, and the names given to these subunits are based upon the apparent molecular mass of the mammalian subunits on SDS-PAGE. The light or lowest (NF-L) runs at 68-70 kD, the medium or middle (NF-M) runs at about 145-160 kD, and the heavy or highest (NF-H) runs at 200-220 kD. However, the actual molecular weight of these proteins is considerably lower due to the highly charged C-terminal regions of the molecules. The level of NF gene expression correlates with the axonal diameter, which controls how fast electrical signals travel down the axon. Mutant mice with NF abnormalities have phenotypes resembling amyotrophic lateral sclerosis. NF immunostaining is common in diagnostic neuropathology. It is useful for differentiating neurons (positive for NF) from glia (negative for NF). |
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| Immunogen | Homogenized hypothalami recovered from Fischer 344 rats. |
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| Other Names | SMI-312, SMI312 |
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| Gene, Accession # | Gene ID: 4747, 4744, 4741 |
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| Catalog # | 837904 |
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| Price | |
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| Order / More Info | Neurofilament Marker Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 18794346 |
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