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| Antigenic Specificity | Neurofilament H & M (NF-H/NF-M), Phospho |
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| Clone | SMI 35 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1, κ |
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| Format | biotin conjugate |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Immunofluorescence Microscopy (IF), IHC-F |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Biotin anti-Neurofilament H & M (NF-H/NF-M), Hypophosphorylated. Neurofilaments (NFs) are approximately 10 nanometer intermediate filaments found in neurons. They are a major component of the neuronal cytoskeleton, and function primarily to provide structural support for the axon and to regulate the axon diameter. There are three major NF subunits, and the names given to these subunits are based upon the apparent molecular mass of the mammalian subunits on SDS-PAGE. The light or lowest neurofilament (NF-L) runs at 68-70 kD. The medium or middle (NF-M) runs at about 145-160 kD, and the heavy or highest (NF-H) runs at 200-220 kD. However, the actual molecular weight of these proteins is considerably lower due to the highly charged C-terminal regions of the molecules. The level of NF gene expression correlates with the axonal diameter, which controls how fast electrical signals travel down the axon. Mutant mice with NF abnormalities have phenotypes resembling amyotrophic lateral sclerosis. NF immunostaining is common in diagnostic neuropathology. It is useful for differentiating neurons (positive for NF) from the glia (negative for NF). |
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| Immunogen | n/a |
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| Other Names | Neurofilament heavy polypeptide, NF-H, 200 kD neurofilament protein, neurofilament triplet H protein |
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| Gene, Accession # | Gene ID: 4744 |
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| Catalog # | 835606 |
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| Price | |
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| Order / More Info | Neurofilament H & M (NF-H/NF-M), Phospho Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 21278408 |
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