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產(chǎn)品名稱

YES1 / c-Yes Antibody from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-C500040

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

Edit	&nbsp
Antigenic Specificity	YES1 / c-Yes
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human
Isotype	n/a
Format	Protein G purified
Size	n/a
Concentration	n/a
Applications	ELISA, IF, IHC, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	YES1 / c-Yes Antibody LS-C500040. Specificity: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
Immunogen	Recombinant human Tyrosine-protein kinase Yes protein (1-155AA)
Other Names	YES1, C-yes, Cyes, Cellular yes-1 protein, HsT441, Oncogene kinase yes1, p61-YES, p61yes, p62c-yes, Proto-oncogene c-Yes, Tyrosine-protein kinase Yes, Yes kinase, v-yes, Yes, Yamaguchi sarcoma oncogene
Gene, Accession #	YES1, Gene ID: 7525
Catalog #	LS-C500040
Price
Order / More Info	YES1 / c-Yes Antibody from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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