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產(chǎn)品名稱(chēng)

Nicastrin, Human (Control Peptide) from UNITED STATES BIOLOGICAL

產(chǎn)品貨號(hào)

N2525-01

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100ug

產(chǎn)品品牌

UNITED STATES BIOLOGICAL

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Nicastrin, Human (Control Peptide)
Description	Highly purified. A 19 aa peptide within the c-terminus of human nicastrin (1). Beta-amyloid (Ab) deposition in the brain is the hallmark of Alzheimer's Disease (AD). To initiate Ab formation, b-secretase cleaves APP at the N-terminus of Ab to release APPsb (~100kD soluble NT-fragment), and C99, a 12-kD CT membrane fragment. Alternatively, a-secretase cleaves within the Ab to prevent the formation of Ab. Cleavage by a-secretase produces a soluble N-terminal fragment, APPsa, and a 10-kD membrane C-terminal fragment, C83. Both C99 and C83 can be further cleaved by g-secretase releasing Ab and a nonpathogenic p3 peptide, respectively. Both Presenilins and a newly discovered protein, Nicastrin are required for this activity. Nicastrin may act to position the APP stub correctly to allow presenilin to cut it at the right place; or it might regulate the activity of the g-secretase enzyme (possibly presenilin). Suppression of nicastrin expression in C. elegans embryos induces a subset of notch/
Size	100ug
Concentration	n/a
Applications	ELISA
Other Names	n/a
Gene, Accession, CAS #	n/a
Catalog #	N2525-01
Price
Order / More Info	Nicastrin, Human (Control Peptide) from UNITED STATES BIOLOGICAL
Product Specific References	n/a
產(chǎn)品資料

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