| 產(chǎn)品詳情 |
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| Antigenic Specificity | Sequestosome 1 (SQSTM1) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress, and autophagy . It was first identified as a protein that binds to the SH2 domain of p56Lck , and independently found to interact with PKCzeta . SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome . Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-kappaB pathway . Protein aggregates formed by SQSTM1 can be degraded by the autophagosome . SQSTM1 binds autophagosomal membrane protein LC3/Atg8, bringing SQSTM1-containing protein aggregates to the autophagosome . Lysosomal degradation of autophagosomes leads to a decrease in SQSTM1 levels during autophagy, conversely, autophagy inhibitors stabilize SQSTM1 levels. Studies have demonstrated a link between SQSTM1 and oxidative stress. SQSTM1 interacts with KEAP1, which is a cytoplasmic inhibitor of NRF2, a key transcription factor involved in cellular responses to oxidative stress . Thus, accumulation of SQSTM1 can lead to an increase in NRF2 activity. Synonyms: SQSTM1,A170,OSIL,PDB3,ZIP3,p60,p62,p62B , |
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| Immunogen | Recombinant protein of human SQSTM1 |
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| Other Names | SQSTM1|sqstm1|MGC79491|A170|OSIL|PDB3|ZIP3|p60|p62|p62B|OSF-6|Osi|STAP|ZIP|sb:cb621|zgc:85784 |
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| Gene, Accession # | Gene ID: 8878,18412,113894 |
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| Catalog # | ABIN1684012 |
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| Price | |
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| Order / More Info | Sequestosome 1 (SQSTM1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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