| 產(chǎn)品詳情 |
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| Antigenic Specificity | beta Amyloid |
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| Clone | 2C8 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG2b |
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| Format | purified |
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| Size | 50 μg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 10 μg/mL, Western Blot: 0.5-1 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | beta Amyloid Monoclonal Antibody (2C8). Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The |
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| Immunogen | n/a |
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| Other Names | Abeta, APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4 |
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| Gene, Accession # | Entrez: 11820, 351; Uniprot: P05067, P12023 |
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| Catalog # | MA1-25493 |
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| Price | |
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| Order / More Info | beta Amyloid Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 17965458 |
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