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產(chǎn)品名稱

Nicastrin Antibody from INVITROGEN ANTIBODIES

產(chǎn)品貨號(hào)

PA1-758

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

INVITROGEN ANTIBODIES

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Nicastrin
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human, mouse, rat
Isotype	n/a
Format	purified
Size	100 μg
Concentration	n/a
Applications	Western Blot: 2 μg/mL
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Nicastrin Polyclonal Antibody. Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, re
Immunogen	n/a
Other Names	Ncstn
Gene, Accession #	Entrez: 23385, 289231, 59287; Uniprot: P57716, Q8CGU6, Q92542
Catalog #	PA1-758
Price
Order / More Info	Nicastrin Antibody from INVITROGEN ANTIBODIES
Product Specific References	PubMed: 12471034, 15123598, 16945923, 21725313, 21852538, 23472157, 23663107, 24145027, 25614624
產(chǎn)品資料

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