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產(chǎn)品名稱

Presenilin 1 Antibody from INVITROGEN ANTIBODIES

產(chǎn)品貨號(hào)

PA5-20376

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 ug

產(chǎn)品品牌

INVITROGEN ANTIBODIES

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Presenilin 1
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human, mouse, rat
Isotype	n/a
Format	purified
Size	100 ug
Concentration	n/a
Applications	Immunocytochemistry: 20 μg/mL, Immunofluorescence: 20 μg/mL, Immunohistochemistry: 2.5 μg/mL, Western Blot: 0.5-2 μg/mL
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Presenilin 1 Polyclonal Antibody. Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-se
Immunogen	n/a
Other Names	AD3, FAD, PS-1, PS1, S182; presenilin-1
Gene, Accession #	Entrez: 19164, 29192, 5663; Uniprot: P49768, P49769, P97887
Catalog #	PA5-20376
Price
Order / More Info	Presenilin 1 Antibody from INVITROGEN ANTIBODIES
Product Specific References	n/a
產(chǎn)品資料

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