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        產(chǎn)品名稱 Human PSEN2 (N-terminal, aa 31-47) Antibody from CREATIVE DIAGNOSTICS
        產(chǎn)品貨號 CABT-L533
        產(chǎn)品價格 現(xiàn)貨詢價,電話:010-67529703
        產(chǎn)品規(guī)格 n/a
        產(chǎn)品品牌 CREATIVE DIAGNOSTICS
        產(chǎn)品概述
        產(chǎn)品詳情
        Edit&nbsp
        Antigenic SpecificityHuman PSEN2 (N-terminal, aa 31-47)
        Clonepolyclonal
        Host SpeciesGoat
        Reactive Specieshuman
        Isotypen/a
        Formatunconjugated
        Sizen/a
        Concentrationn/a
        ApplicationsELISA, IHC, WB
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionGoat Anti-Human PSEN2 (N-terminal) polyclonal antibody for ELISA, IHC, WB. The presenilin-2 (PS-2) gene was discovered on chromosome 1 and is responsible for an early onset form of autosomal dominant Alzheimer`s disease (AD). The amino acid sequence is approximately 67% identical with that of the PS-1 protein. It also is a membrane protein that has regions where mutations have been identified in family members with AD. The gene sequence of PS-2 does not match any known human gene sequences, except for that of PS-1; but has been found to be a new class of aspartic-proteases. It has now been identified as one of the β-secretase proteases. Alzheimer`s disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid β-peptide (Aβ). Aβ generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of Aβ by β-secretase (BACE). The Aβ peptide is then released by proteolytic cleavage at its C-terminus by β-secretase (presenilins). Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes.
        ImmunogenPeptide (CQEGRQGPEDGENTAQW)
        Other Namesn/a
        Gene, Accession #Gene ID: 5664, UniProt: P49810
        Catalog #CABT-L533
        Price
        Order / More InfoHuman PSEN2 (N-terminal, aa 31-47) Antibody from CREATIVE DIAGNOSTICS
        Product Specific Referencesn/a
        產(chǎn)品資料
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