| Description | Recombinant Human NGF Beta: beta-Nerve Growth Factor/beta-NGF was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits alpha, beta, and gamma, it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Beta-NGF is a neurotrophic factor that signals through its receptor beta-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that beta-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Recombinant Human NGF Beta shares 90% sequence similarity with mouse protein and shows cross-species reactivity.ReferencesForsell P, et al. The use of TrkA-PathHunter assay in high-throughput screening to identify compounds that affect nerve growth factor signaling.PMID: 23458757http://www.ncbi.nlm.nih.gov/pubmed/23458757Alternative Names: Recombinant Human NGF Beta, Beta-Nerve Growth Factor, Beta-NGF, NGF, NGFB |
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