| 產(chǎn)品詳情 |
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| Antigenic Specificity | Estrogen Receptor 1 (ESR1) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Estrogen receptor alpha (ERalpha), a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD) . Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERalpha regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery . Phosphorylation provides an important mechanism to regulate ERalpha activity . ERalpha is phosphorylated on multiple sites . Ser104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ERalpha activity. Ser118 may be the substrate of the transcription regulatory kinase CDK7 . Ser167 may be phosphorylated by p90RSK and Akt . Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients . Synonyms: ESR1,DKFZp686N23123,ER,ESR,ESRA,Era,NR3A1 , Estrogen Receptor alpha |
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| Immunogen | Recombinant protein of human ESR1 |
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| Other Names | ACTGP1|ACT1GP1|HY-psi-gamma-AC6|ER[b]2|ER[b]a|zfER[b]2|zfER-beta2|XER|era|esr|esra|nr3a1|ERbeta|xesr-1|ERalpha|xlERalpha1|xlERalpha2|LOC398733|LOC398734|2610524P08Rik|9130407C09Rik|AU019798|Era|M-ERA|MERA-S|MERA-W|ERA|ERAL1A|H-ERA|HERA-A|HERA-B|er|esr1|ER|ESR|ESRA|ESTRR|NR3A1|ER-alpha|Esr|RNESTROR|ERALPHA|ER[a]|eralpha|zfER[a]|ESR1|AA420328|AU041214|ERa|Estr|Estra|Nr3a1 |
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| Gene, Accession # | Gene ID: 2099,13982,24890 |
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| Catalog # | ABIN1683567 |
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| Price | |
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| Order / More Info | Estrogen Receptor 1 (ESR1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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