| 產(chǎn)品詳情 |
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| Antigenic Specificity | Estrogen Receptor 2 (ER Beta) (ESR2) (aa 27-50), (N-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Estrogen receptor-beta, referred to as ESR2, is a member of the superfamily of nuclear receptors, which can transduce extracellular signals into transcriptional responses. This gene is mapped to 14q and comprises 8 exons spanning approximately 40 kb. ESR2 is expressed in multiple tissues, including developing spermatids of the testis and in ovarian granulosa cells. ESR-beta is homologous to the previously identified ESR-alpha and has an overlapping but nonidentical tissue distribution. The DNA-binding domain of ESR-beta is 96% conserved compared to ESR, and the ligand-binding domain shows 58% conserved residues. ESR-beta is expressed in human thymus, spleen, ovary, and testis. Rat ESR-beta is expressed in rat prostate and ovary and is homologous to rat ESR(95% conserved DNA-binding domain, 55% conserved ligand-binding domain). ESR2 mRNA was coexpressed with ESR1 and its splice variants in 60% of prolactinomas, 100% of mixed growth hormone /prolactin tumors, and 29% of gonadotroph tumors. ESR2 gene expression was not limited to ESR1-positive tumor subtypes, however, and was also found in 100% of null cell tumors, 80% of somatotroph tumors, and 60% of corticotroph tumors. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human Estrogen Receptor beta(27-50aa HGSIYIPSSYVDSHHEYPAMTFYS), different from the related rat and mouse sequences by four amino acids. |
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| Other Names | ER[b]1|zfER-beta1|zfER[b]1|erb|esrb|estrb|nr3a2|ERbeta|er-beta|esr-beta|ESR2|er|esr2|erb2|erb1|ER-beta|ER[b]|Estrb|ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2|Erb2|ERB|ERBETA|CERB|ERBeta2|erbeta|Esr2 |
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| Gene, Accession # | Gene ID: 2100 |
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| Catalog # | ABIN343402 |
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| Price | |
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| Order / More Info | Estrogen Receptor 2 (ER Beta) (ESR2) (aa 27-50), (N-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 22314839, 20869049, 21505981, 8650195, 9398750, 8769313 |
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