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產(chǎn)品名稱

Noggin (NOG) (Active) protein from ANTIBODIES-ONLINE GmbH

產(chǎn)品貨號

ABIN804557

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

5 μg

產(chǎn)品品牌

ANTIBODIES-ONLINE GmbH

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Noggin (NOG) (Active) protein
Description	The secreted polypeptide noggin, encoded by the NOG gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified, both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as NOG. All NOG mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of human noggin is highly homologous to that of Xenopus, rat and mouse Synonyms: SYM1, SYNS1, NOG
Size	5 μg
Concentration	n/a
Applications	n/a
Other Names	noggin\|SYM1\|SYNS1\|nog-A\|nog1\|noggin-1
Gene, Accession, CAS #	Gene ID: 9241
Catalog #	ABIN804557
Price
Order / More Info	Noggin (NOG) (Active) protein from ANTIBODIES-ONLINE GmbH
Product Specific References	n/a
產(chǎn)品資料

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