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產(chǎn)品名稱

XPO1 / CRM1 Antibody from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-C500034

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	XPO1 / CRM1
Clone	polyclonal
Host Species	Rabbit
Reactive Species	mouse, human
Isotype	n/a
Format	Protein G purified
Size	n/a
Concentration	n/a
Applications	ELISA, IF, IHC, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	XPO1 / CRM1 Antibody LS-C500034. Specificity: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Immunogen	Recombinant Human Exportin-1 protein (625-845AA)
Other Names	XPO1, CRM1, yeast, homolog, Exp1, Exportin-1, CRM1
Gene, Accession #	XPO1, Gene ID: 7514
Catalog #	LS-C500034
Price
Order / More Info	XPO1 / CRM1 Antibody from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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