| 產(chǎn)品詳情 |
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| Antigenic Specificity | PICK1 |
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| Clone | L20/8 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-PICK1. Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. (Uniprot) |
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| Immunogen | This monoclonal antibody was raised against a fusion protein corresponding to amino acids 10-130 of rat PICK1 protein. |
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| Other Names | PRKCA-binding protein, protein interacting with C kinase 1, protein kinase C-alpha-binding protein, protein that interacts with C kinase 1, protein kinase C, alpha binding protein, PRKCABP, MMS-5179-100 |
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| Gene, Accession # | Gene ID: 84591 |
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| Catalog # | 830901 |
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| Price | |
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| Order / More Info | PICK1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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