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        產(chǎn)品名稱 COMT (Extracellular) Antibody from CREATIVE DIAGNOSTICS
        產(chǎn)品貨號 CABT-B1631
        產(chǎn)品價格 現(xiàn)貨詢價,電話:010-67529703
        產(chǎn)品規(guī)格 n/a
        產(chǎn)品品牌 CREATIVE DIAGNOSTICS
        產(chǎn)品概述
        產(chǎn)品詳情
        Edit&nbsp
        Antigenic SpecificityCOMT (Extracellular)
        Clonepolyclonal
        Host SpeciesRabbit
        Reactive Specieshuman
        Isotypen/a
        Formatunconjugated
        Sizen/a
        Concentrationn/a
        ApplicationsWB, IHC
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionRabbit Anti-Human COMT polyclonal antibody for WB, IHC. Catechol O-methyltransferase (EC 2.1.1.6; UniProt P21964) is encoded by the COMT gene (Gene ID 1312) in human. Catechol-O-methyltransferase initiates the metabolic breakdown of catecholamines (including the neurotransmitters dopamine, epinephrine, and norepinephrine) by catalyzing the transfer of a methyl group from S-adenosylmethionine (SAM) to catecholamines in the presence Mg++. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to endogenous substances, COMT is also important in the metabolism of catechol drugs. Two isoforms exist as a result of alternative initiation codon usage. The membrane-bound isoform or MB-COMT contains a short N-terminal cytoplasmic tail (a.a. 1-6), a transmembrane segment (a.a. 7-26), and a large C-terminal extracellular region (a.a. 27-271), while the soluble or S-COMT isoform lacks the N-terminal 50-amino acid sequence of MB-COMT. MB-COMT and S-COMT differ in their substrate affinity and capacities. Despite having a lower capacity than S-COMT, MB-COMT has around a 10-fold greater affinity for dopamine and noradrenaline, and therefore is likely to be better suited for metabolizing catecholamines at the concentrations found in brain. The influence of the Val(158)Met polymorphic form of catechol-o-methyltransferase (COMT) on brain activation and functional connectivity is the subject of numerous studies.
        ImmunogenKLH-conjugated linear peptide corresponding to an extracellular domain sequence of human catechol O-methyltransferase.
        Other Namesn/a
        Gene, Accession #Gene ID: 1312, UniProt: P21964
        Catalog #CABT-B1631
        Price
        Order / More InfoCOMT (Extracellular) Antibody from CREATIVE DIAGNOSTICS
        Product Specific Referencesn/a
        產(chǎn)品資料
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