| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Sortilin 1 (SORT1) (Cytoplasmic Domain) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | unconjugated |
|---|
| Size | 500 μg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Function: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.Subunit: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB). Interacts with the precursor form of BDNF (proBDNF).Subcellular location: Membrane, Single-pass type I membrane protein. Note: Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin. Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes.Tissue specificity: Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. Also known as: Neurotensin receptor 3, NTR3, NT3, Glycoprotein 95, Gp95, 100 kDa NT receptor. |
|---|
| Immunogen | A synthetic peptide from the cytoplasmic domain of human Sortilin (Neurotensin receptor 3, NTR3, Sort1) conjugated to an immunogenic carrier protein was used as the immunogen. |
|---|
| Other Names | SORT1|19.m02079|gp95|ldlcq6|sortilin|Gp95|LDLCQ6|NT3|2900053A11Rik|AI852375|Ntr3|Ntsr3|Nt3|Nts3|sort1|zgc:85953 |
|---|
| Gene, Accession # | Gene ID: 6272 |
|---|
| Catalog # | ABIN350865 |
|---|
| Price | |
|---|
| Order / More Info | Sortilin 1 (SORT1) (Cytoplasmic Domain) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 16710414, 12209882, 12598608, 9756851, 10085125, 11331584, 11859376, 15930396, 18088087, 9013611 |
|---|
| 產(chǎn)品資料 |
|
午夜亚洲,91们嫩草伦理,【无码流出】苍井空
|
国产主播精品,大香蕉人人操,男男视频免费观看网站国产
|
特淫毛片,大尺度电影免费观看完整版高清,无码视频成人
|
亚洲五十路,男女上下摸激情视频,快艹我
|
男女精品视频,午夜久久久久,精品一二三四区
|
欧美三级视频在线,美女粉嫩b,精品国语对白69
|
成人影片中文字幕,警花的奶水h系列小说,豆花视频在线播放
|
台湾三级精品三级在专区,女上男下男人吃奶xx00动态图,婷婷丁香五月天久久
|
亚洲国产精品成人综合,被添出水全过程视频,经典无码一区二区三区
|
自拍偷拍第3页,男男高潮视频,俺去啦在线视频
|
|