| 產(chǎn)品詳情 |
| Edit |   |
| Product Name | NMDA Antagonist XI, N1-dansyl-spermine (NMDA Channel Blocker, N1-dansyl-spermine, N1-DnsSpm) |
| Description | Purity ~97% (HPLC). An N-sulfonyl-polyamine that acts as a potent and more specific antagonist ofnMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13uM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58uM) and diminishes the induction of ornithine decarboxylase. At higher concentration (?100uM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices. Solubility: DMSO Primary Target: NMDA Primary Target IC50: 0.31u |
| Size | 10mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | n/a |
| Gene, Accession, CAS # | n/a |
| Catalog # | 217592 |
| Price | |
| Order / More Info | NMDA Antagonist XI, N1-dansyl-spermine (NMDA Channel Blocker, N1-dansyl-spermine, N1-DnsSpm) from UNITED STATES BIOLOGICAL |
| Product Specific References | n/a |
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