| 產(chǎn)品詳情 |
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| Antigenic Specificity | LGR5 |
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| Clone | BEE-6F7 |
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| Host Species | Rat |
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| Reactive Species | human |
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| Isotype | IgG2a/kappa |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | flow cytometry, CELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LGR5 (Leucine-rich repeat- containing G protein-coupled receptor 5), also known as GPR49. belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 907 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues. LGR5 is a member of the Wnt signaling pathway. Although its ligand remains elusive, it has been shown that costimulation with R-spondin 1 and Wnt-3a induce increased internalization of LGR5. LGR5 is overexpressed in certain cancer types, e.g. gastrointestinal tumours and is thought to represent a tumour suppressor, although its role there is still unclear. |
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| Immunogen | cDNA |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | GM-0607 |
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| Price | |
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| Order / More Info | LGR5 Antibody from ALDEVRON FREIBURG GmbH |
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| Product Specific References | n/a |
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