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產(chǎn)品名稱

Activin A Antibody from BIOLEGEND

產(chǎn)品貨號(hào)

693604

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

1 mg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Activin A
Clone	A15095A
Host Species	Mouse
Reactive Species	human
Isotype	IgG2b, κ
Format	purified, azide-free
Size	1 mg
Concentration	n/a
Applications	Neut
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Ultra-LEAF? Purified anti-Activin A. Activin A was initially identified in ovarian fluid as a stimulator of FSH secretion from anterior pituitary cells. Activin A is a member of the TGFb1 family which includes TGFs, Activins, Nodal, growth and differentiation factors (GDF), and bone morphogenetic proteins (BMPs). Activin A is a dimer of the beta A subunits of human inhibin; the beta A subunit binds the beta B subunit of inhibin to form Activin AB. The beta B subunit also exists as a heterodimer to form Activin B. Activin A binds two type I and two type II serine/threonine kinase receptors at the same time. The type II receptor kinase is constitutively active and phosphorylates the type I receptor after the formation of the ligand-receptor complex. Five type II receptors have been identified: ActRIIA, ActRIIB, BMPRII, TGFβRII, and MISRII. ActRIIB binds to Activin A, BMP-2, BMP-7, GDF-8, and GDF-11. The type I receptors are named activin receptor-like kinases 1 to 7 (ALK1~7), and Activins bind to ALK4 and ALK7. Follistatin (FS) is a natural Activin A antagonist; FS neutralizes its biologic activities by preventing Activin A interaction with its receptors. Activin A has pleiotropic functions. It is a morphogen during embryonal development, regulating chondrogenic and osteogenic differentiation of mesenchymal progenitor cells (MPC). Activin A has been associated with neuroprotection, apoptosis, and fibrosis. Also, high levels of Activin A have been found in synovial fluid from patients with rheumatoid arthritis, inflammatory bowel disease, and gout. In addition, it has been speculated that Activin A, in collaboration with TGFb1 and IL-25, promotes TH9 generation and the development of allergic pathology.
Immunogen	Recombinant human Activin A.
Other Names	Inhibin BA (INHBA), Inhibin B-1, Follicule stimulating hormone-releasing protein (FRP), FSH releasing protein, FSH releasing factor, Erythroid differentiation factor (EDF)
Gene, Accession #	Gene ID: 3624
Catalog #	693604
Price
Order / More Info	Activin A Antibody from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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