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產(chǎn)品名稱

Aggrecan Antibody from BIOLEGEND

產(chǎn)品貨號

674902

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

Edit	&nbsp
Antigenic Specificity	Aggrecan
Clone	M4004A03
Host Species	Mouse
Reactive Species	human
Isotype	IgG
Format	purified
Size	100 μg
Concentration	n/a
Applications	Western Blot (WB)
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Purified anti-Aggrecan. Aggrecan, also known as aggrecan 1, is the major proteoglycan in the articular cartilage. This high molecular weight protein exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. Aggrecan plays an important role in the proper functioning of articular cartilage by providing a hydrated gel structure through its interaction with hyaluronan and link proteins. Aggrecan is expressed by chondrocytes and is found to be crucial in chondroskeletal morphogenesis during development. Mutations in this gene may be involved in skeletal dysplasia and spinal cord degeneration. Structurally, aggrecan is composed of two globular domains (G1 and G2) at the N-terminal end and one globular domain (G3) at the C-terminal end, which are separated by a large extended domain (CS) heavily modified with glycosaminoglycans. G1 and G2 domains of aggrecan are separated by the interglobular domain (IGD). Biologically, the G1 domain interacts with hyaluronan acid and link proteins, which forms stable ternary complexes in the extracellular matrix (ECM). The G2 domain is homologous to the tandem repeats of G1 and link proteins, and is involved in product processing. G3 makes up the carboxyl terminus of the core protein, and enhances glycosaminoglycan modification and product secretion. Also, the G3 domain links the proteoglycan aggregates to the ECM proteins, which are fibulins and tenascins. The degradation of aggrecan appears to initiate at the C-terminus. The population of aggrecan molecules without the G3 domain increases with aging.
Immunogen	Recombinant human Aggrecan produced in 293E cells.
Other Names	Aggrecan 1, AGC1, Aggrecan Proteoglycan, Chondroitin Sulfate Proteoglycan 1, Cartilage-Specific Proteoglycan Core Protein, CSPG1, MSK16, CSPGCP, SEDK and CSPCP
Gene, Accession #	Gene ID: 176
Catalog #	674902
Price
Order / More Info	Aggrecan Antibody from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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