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產(chǎn)品名稱

AIM2 Antibody from BIOLEGEND

產(chǎn)品貨號

652801

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

Edit	&nbsp
Antigenic Specificity	AIM2
Clone	3B10
Host Species	Mouse
Reactive Species	human
Isotype	IgG1, κ
Format	purified
Size	25 μg
Concentration	n/a
Applications	Western Blot (WB), Immunofluorescence Microscopy (IF), IP
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Purified anti-AIM2. AIM2 is one of the human IFN-inducible proteins, encoding a 39 kD protein. It contains a 200 amino acid repeat, which is a signature of the HIN-200 family (hematopoietic IFN-inducible nuclear proteins). Expression of AIM2 can inhibit cell growth and tumor formation, possibly through inducing apoptosis and suppressing nuclear factor-κ B transcriptional activity and desensitizing tumor necrosis factor-alpha-mediated nuclear factor-κ B activation. Furthermore, the gene for AIM2 shows a high frequency of mutations that are associated with microsatellite unstable colorectal cancers. AIM2 plays a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1β and IL-18. AIM2 is also essential for mediating inflammatory reactions triggered by cytoplasmic DNA. AIM2 is an important sensor for different pathogens through the binding of cytoplasmic double-stranded DNA through HIN-200 domain and formation of inflammatsomes including ASC/AIM2. This complex then triggers caspase-1 activation. Recent studies also show that AIM2/ASC complex acts as a novel caspase-8 activation platform.
Immunogen	Recombinant fragment, corresponding to amino acids 1-186 of human AIM2 with a GST tag.
Other Names	Absent in melanoma 2, PYHIN4, interferon-inducible protein AIM2
Gene, Accession #	Gene ID: 9447
Catalog #	652801
Price
Order / More Info	AIM2 Antibody from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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