| 產品詳情 |
| Edit |   |
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| Antigenic Specificity | AKT2 |
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| Clone | P81B6 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG2b |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-AKT2. AKT (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis, and tumor formation. There are three isoforms of AKT- AKT1, 2, and 3, which are also known as PKBα, β, and γ). Increasing evidence suggests that AKT1, 2, and 3 plays an unique role in breast cancer initiation and progression. AKT2 is amplified or overexpressed in cancer with a higher frequency than those found with AKT1. AKT2 is also closely linked to Type II diabetes and is a pivotal player in the Phosphatidylinositol 3 kinase/Akt/Mammalian target of rapamycin (PI3K/mTOR) signaling axis. The deregulation of AKT2 has been associated with acquisition of stem cell-like properties, responsible for invasiveness and tumor progression, metastatic spread, and chemoresistance. |
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| Immunogen | Purified recombinant fragment (a.a. 2-149) of human AKT2 expressed in E. coli. |
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| Other Names | V-Akt Murine Thymoma Viral Oncogene Homolog 2, Protein Kinase B Beta, Rac Protein Kinase Beta, RAC-PK-Beta, PKB Beta, PRKBB, PKBB, HIHGHH, PKBBETA, RAC-BETA |
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| Gene, Accession # | Gene ID: 208 |
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| Catalog # | 680202 |
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| Price | |
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| Order / More Info | AKT2 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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