| 產(chǎn)品詳情 |
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| Antigenic Specificity | α-E-Catenin |
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| Clone | 1G5 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1, κ |
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| Format | purified, azide-free |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Immunofluorescence Microscopy (IF), Western Blot (WB), IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Ultra-LEAF? Purified anti-α-E-Catenin. α-catenin associates with the cytoplasmic domain of a variety of plasma membrane spanning cadherins that mediate cell-cell adhesion. The association of catenins to cadherins produces a complex that is linked to the actin filament network, which seems to be of primary importance for their cell-adhesion properties. Catenin can associate with both E- and N-cadherins. It was originally thought to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and α-catenin was shown not to bind to F-actin when assembled in the complex suggesting a more complex, dynamic linkage between actin and these adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. |
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| Immunogen | Recombinant human MBP-alpha catenin fusion protein. |
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| Other Names | Catenin (Cadherin-Associated Protein), Alpha 1, 102kD, Alpha-1-Catenin, Alpha E-Catenin , Cadherin-Associated Protein,102 kD, CAP102, CTNNA1 |
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| Gene, Accession # | Gene ID: 1495 |
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| Catalog # | 844803 |
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| Price | |
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| Order / More Info | α-E-Catenin Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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