| 產(chǎn)品詳情 |
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| Product Name | AAL-993 |
| Description | AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM) and VEGFR-3 (IC50 = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model). MW: 371.36. Purity ≥98% by TLC |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide |
| Gene, Accession, CAS # | CAS: 269390-77-4 |
| Catalog # | 2740-10 |
| Price | |
| Order / More Info | AAL-993 from BIOVISION, INC. |
| Product Specific References | n/a |
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