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產(chǎn)品名稱

Alpha-Ketoglutarate Dehydrogenase Activity Colorimetric Assay Kit from CREATIVE BIOMART

產(chǎn)品貨號(hào)

Kit-2206

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 assays

產(chǎn)品品牌

CREATIVE BIOMART

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Alpha-Ketoglutarate Dehydrogenase Activity Colorimetric Assay Kit
Description	α-Ketoglutarate Dehydrogenase (α-KGDH) (EC 1.2.4.2) is a key enzyme in the citric acid cycle. It forms an enzyme complex with dihydrolipoamide succinyl transferase (E2) and dihydrolipoamide dehydrogenase (E3).α-KGDH converts α-ketoglutarate into succinyl-CoA in the presence of NAD and CoA. It is highly regulated by intracellular ATP/ADP and NADH/NAD ratios and calcium. In humans, decreased KGDH activity can lead to neurodegenerative diseases such as Alzheimer's disease. Recent studies show that α-KGDH is a target of oxidative stress; reactive oxygen species (ROS) inhibit KGDH activity which diminishes its critical function and can cause a bioenergetic deficit.α-KGDH assay kit provides a quick and easy way for monitoring α-KGDH activity in various samples. In the assay, α-KGDH converts α-ketoglutarate into an intermediate which reduces the probe to a colored product with strong absorbance at 450 nm. The assay is simple, sensitive and can detect α-ketoglutarate dehydrogenase activity lower than 0.1 mU in a variety of samples.
Size	100 assays
Concentration	n/a
Applications	Measurement of α-Ketoglutarate dehydrogenase activity in various tissues/cells. Analysis of cell signaling pathways such as citrate acid cycle, lysine degradation or tryptophan metabolism in various cell types.
Other Names	n/a
Gene, Accession, CAS #	n/a
Catalog #	Kit-2206
Price
Order / More Info	Alpha-Ketoglutarate Dehydrogenase Activity Colorimetric Assay Kit from CREATIVE BIOMART
Product Specific References	n/a
產(chǎn)品資料

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