| 產(chǎn)品詳情 |
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| Antigenic Specificity | PD-1 |
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| Clone | NAT105 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 500 μl |
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| Concentration | n/a |
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| Applications | IHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot, Immunoprecipitation, Immunofluorescence, Flow Cytometry |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Anti-PD-1 antibody clone NAT105 is suitable for the immunohistological detection of Follicular helper T cells (TFH), Tumor-infitrating T cells (TILs) whose anti-tumor activity is inhibited by PD-1, Lymphomas derived from TFH cells including Angioimmunoblastic T-cell lymphoma, Primary cutaneous CD4-positive small/medium T-cell lymphoma, Follicular variant of peripheral T-cell lymphoma NOS. Moreover, monoclonal antibodies to PD1 and PDL1 are currently being investigated in clinical trials for their potential to inhibit this pathway with the effect of elevated tumor immunity - Background: PD-1 plays a key role in peripheral tolerance and autoimmune disease. Several tumors express ligand for PD1 (PDL1). On binding activated T cells in the tumor microenvironment, PD-1 inactivates antigen specific T cells that would other-wise attack tumor cells. |
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| Immunogen | TY cells (human T/NK Leukemia) |
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| Other Names | Programmed Cell Death 1, PD-1, CD279, PDCD1, SLEB2 |
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| Gene, Accession # | PDCD1, 5133 |
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| Catalog # | DIA-PD1-P01 |
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| Price | |
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| Order / More Info | PD-1 Antibody from DIANOVA GmbH |
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| Product Specific References | Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma.Roncador, G., Verdes-Montenegro, J.F.G., Tedoldi, S., Paterson, J.C., Klapper, W., Ballabio, E., Maestre, L., Pileri, S., Hansmann, M.L., Piris, M.A., Mason, D.Y., Marafioti, T. Haematologica. 2007 Aug;92(8):1059-66. |
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