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        產品名稱 B-CK, Human Antibody from HYCULT BIOTECH
        產品貨號 HM2110
        產品價格 現貨詢價,電話:010-67529703
        產品規(guī)格 100 μg
        產品品牌 HYCULT BIOTECH
        產品概述
        產品詳情
        Edit&nbsp
        Antigenic SpecificityB-CK, Human
        CloneCK-BYK/21E1
        Host SpeciesMouse
        Reactive Specieshuman, mouse, rabbit, rat
        IsotypeIgG2b
        Formatunconjugated
        Size100 μg
        Concentration100 μg/ml
        Applicationsfrozen sections, IF, paraffin sections, WB
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionThe monoclonal antibody CK-BYK/21E10 recognizes human creatine kinase B-type, also known as B-CK. Human B-CK is a protein of 381 amino acids (~45 kDa), expressed in a number of tissues. B-CK is most abundant in adult brain, approx. 5-fold lower in the stomach, 10-fold lower in the heart and barely detectable in liver. In brain, whereas most B-CK has been shown to be cytosolic, several of the reactions requiring B-CK are membrane-associated. B-CK belongs to the creatine kinase (CK) isoenzymes that catalyse the synthesis of phosphocreatine (PCr) and its subsequent use in the regeneration of ATP in cell types where the consumption of ATP is rapid and/or sudden. In the brain the different CK isoforms constitute an energy shuttle wherein ATP produced in the mitochondria is used by a mitochondrial CK [e.g. ubiquitous mitochondrial creatine kinase (uMi-CK)] to generate PCr, which is then transported and used by a cytoplasmic CK [e.g. brain creatine kinase (B-CK)] to regenerate ATP at discrete cellular sites of high ATP turnover. B-CK appears to have a role in regenerating ATP needed for the transport of ions and neurotransmitters since CKB has been localized to brain synaptic plasma membranes, possibly coupled to Na+/K+-ATPase and acetylcholine receptor-rich membranes. Expression of B-CK is developmentally controlled: in rat, brain CK protein at birth is extremely low and increases 10-fold until week 4. This reflects the many energy-demanding processes in brain during brain development.
        ImmunogenSynthetic 17-mer peptide corresponding to the N-terminal sequence of human creatine kinase brain-type (SNSHNALKLRFPAEDEF)
        Other NamesCreatine kinase B chain, B-CK.
        Gene, Accession #CKB, CKBB
        Catalog #HM2110
        Price
        Order / More InfoB-CK, Human Antibody from HYCULT BIOTECH
        Product Specific Referencesn/a
        產品資料
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