| 產(chǎn)品詳情 |
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| Antigenic Specificity | C5aR, Human |
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| Clone | S5/1 |
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| Host Species | Mouse |
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| Reactive Species | human, rabbit |
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| Isotype | IgG2a |
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| Format | unconjugated |
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| Size | 100 μg |
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| Concentration | 100 μg/ml |
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| Applications | frozen sections, FC, functional studies, paraffin sections, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody S5/1 recognizes the human receptor for C5a (CD88). The C5a receptor- is a seven transmembrane GTP-binding-protein-coupled receptor of 45kDa which binds with high affinity to human anaphylatoxin C5a. Upon C5a binding- G-protein-dependent cellular- responses are initiated such as increased intracellular Ca2+, granule fusion with the cell membrane, enzyme release and oxidative burst suggesting that C5aR is an important mediator of inflammation. The C5a receptor is expressed on a broad range of cell types, including- neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. Interestingly, C5a receptor signalling has been associated with several inflammatory diseases including rheumatoid arthritis.-. Clone S5/1 was raised against a synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31). The antibody has been shown to inhibit the binding of C5a to its receptor. |
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| Immunogen | Synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31) |
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| Other Names | Complement component 5a receptor 1, CD88, C5aR, C5a anaphylatoxin receptor. |
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| Gene, Accession # | n/a |
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| Catalog # | HM2094 |
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| Price | |
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| Order / More Info | C5aR, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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