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產(chǎn)品名稱

Caspase-3, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HP9060

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Caspase-3, Human
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human, mouse, rat
Isotype	n/a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	immunoassay, IF, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The caspase-3 antibody recognizes caspase-3, a member of the peptidase C14A family of enzymes. It is widely expressed and is an integral component of the apoptotic cascade. Caspase-3 is considered to be the major executioner caspase? that is, the primary downstream mediator of apoptotic associated proteolysis. Human pro-caspase-3 is a 32 kDa, 277 amino acid (aa) protein. Normally, it is an inactive, cytosolic homodimer, but following an upstream signal that activates processing proteases, pro-caspase-3 undergoes proteolytic cleavage. Multiple proteases can use caspase 3 as a substrate including caspase-6, -8, and -10, granzyme B, and caspase-3 itself. Active caspase-3 is known to utilize a Cys residue to cleave multiple substrates, including PARP, proIL16, PKCγ & δ, pro-caspases-6, -7 and -9, and βcatenin. Caspase-3 the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. This caspase-3 polyclonal antibody detects endogenous levels of caspase-3 protein.
Immunogen	Synthesized peptide derived from human Caspase-3 around the non-phosphorylation site of S150
Other Names	CASP-3, Apopain, Cysteine protease CPP32, CCP-32, Protein Yama, SREBP cleavage activity 1, SCA-1.
Gene, Accession #	CASP3, CCP32
Catalog #	HP9060
Price
Order / More Info	Caspase-3, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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