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產(chǎn)品名稱

A-443654 from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號

LS-H6353

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	A-443654
Description	Purity >98%. Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBAlpha, Beta, Gamma) modulate cell proliferation, metabolism, and survival as well as angiogenesis. A-443654 is an inhibitor of Akt (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation. It induces G2 /M accumulation, defects in centrosome separation, and formation of either monopolar arrays or disorganized spindles. A-443654 has been reported to slow the progression of Akt-dependent tumors in in vivo mouse models. In response to an A-443654-induced decrease in phosphorylation of Akt targets, a concomitant increase in Thr308 and Ser473 phosphorylation of Akt has been observed in human cancer cell lines. A-443654 has been used to examine the mechanism of this rapid feedback reaction.
Size	n/a
Concentration	n/a
Applications	n/a
Other Names	aS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-1H-indole-3-ethanamine
Gene, Accession, CAS #	CAS: 552325-16-3
Catalog #	LS-H6353
Price
Order / More Info	A-443654 from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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