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產(chǎn)品名稱

A-674563 from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-H6358

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	A-674563
Description	Purity >95%. Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBAlpha, Beta, Gamma) modulate cell proliferation, metabolism, and survival, as well as angiogenesis. A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki = 11 nM for Akt1). It shows inhibitory activity against PKA and Cdk2 with IC50 values of 16 and 46 nM, respectively, but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families. A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4 μM. In vivo, 40 mg/kg/day A-674563 in combination with 15 mg/kg/day paclitaxel was shown to decrease tumor growth in a PC-3 prostate cancer mouse xenograft model.
Size	n/a
Concentration	n/a
Applications	n/a
Other Names	aS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-benzeneethanamine
Gene, Accession, CAS #	CAS: 552325-73-2
Catalog #	LS-H6358
Price
Order / More Info	A-674563 from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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