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產(chǎn)品名稱

A-769662 from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-H14577

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	A-769662
Description	Purity >98% (NMR, HPLC). A-769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the b and g subunits and not the AMP binding site. EC50=0.8 mM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 mM. A-769662 inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice. Inhibits adipocyte differentiation. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming. A-769662 synergizes with AICAR. Cell permeable.
Size	n/a
Concentration	n/a
Applications	n/a
Other Names	4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
Gene, Accession, CAS #	CAS: 844499-71-4
Catalog #	LS-H14577
Price
Order / More Info	A-769662 from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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