| 產(chǎn)品詳情 |
| Edit |   |
| Product Name | A-769662 |
| Description | Purity >98%. AMP-activated protein kinase (AMPK) is an AlphaBetaGamma heterotrimer that functions as a metabolic sensor, regulating lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress. A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172 . A-769662 specifically activates Beta1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress. |
| Size | n/a |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Gene, Accession, CAS # | CAS: 844499-71-4 |
| Catalog # | LS-H6361 |
| Price | |
| Order / More Info | A-769662 from LIFESPAN BIOSCIENCES INC. |
| Product Specific References | n/a |
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