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產(chǎn)品名稱

A-771726 from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-H6362

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	A-771726
Description	Purity >98%. A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50 s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0 /G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-Alpha and IL-1Alpha (IC50 s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.
Size	n/a
Concentration	n/a
Applications	n/a
Other Names	2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide, Flucyamide, HMR 1726, SU 20, Teriflunomide
Gene, Accession, CAS #	CAS: 163451-81-8
Catalog #	LS-H6362
Price
Order / More Info	A-771726 from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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