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產(chǎn)品名稱

A-803467 from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號

LS-H6363

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	A-803467
Description	Purity >98%. Nav 1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav 1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state). 1 This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.
Size	n/a
Concentration	n/a
Applications	n/a
Other Names	5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
Gene, Accession, CAS #	CAS: 944261-79-4
Catalog #	LS-H6363
Price
Order / More Info	A-803467 from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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