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產(chǎn)品名稱

A-804598 from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-H6365

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	A-804598
Description	Purity >98%. A-804598 is a potent and selective competitive antagonist of the purinergic P2X7 receptor, a ligand-gated ion channel, with IC50 values of 9.9 and 10.9 nM in 132N1 cells transfected with the rat or mouse receptor, respectively. It inhibits IL-1Beta release in human THP-1 cells stimulated with LPS and IFN-Gamma (IC50 = 8.5 nM). A-804598 is selective for P2X7 receptors over other P2X and P2Y receptors at concentrations up to 100 μM and over many G protein-coupled receptors, enzymes, transporters, and ion channels. A-804598 (25 mg/kg) prevents footshock-induced increases in IL-1Beta mRNA in the paraventricular nucleus of the rat hypothalamus.
Size	n/a
Concentration	n/a
Applications	n/a
Other Names	N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine
Gene, Accession, CAS #	CAS: 1125758-85-1
Catalog #	LS-H6365
Price
Order / More Info	A-804598 from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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