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產(chǎn)品名稱

A-922500 from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-H6364

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	A-922500
Description	Purity >95%. Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity (DIO) or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively. When administered at 3 mg/kg to DIO mice, A-922500 conferred significant weight loss within seven days without affecting food intake and significantly reduced plasma and liver triglycerides with chronic dosing. A-922500 does not inhibit DGAT-2, ACAT-1, or ACAT-2.
Size	n/a
Concentration	n/a
Applications	n/a
Other Names	2R-[[4'-[[(phenylamino)carbonyl]amino][1R,1'-biphenyl]-4-yl-carbonyl]-cyclopentanecarboxylic acid, (1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid
Gene, Accession, CAS #	CAS: 959122-11-3
Catalog #	LS-H6364
Price
Order / More Info	A-922500 from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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