| 產(chǎn)品詳情 |
| Edit |   |
| Product Name | AAL-993 |
| Description | Purity >98% by NMR, TLC. AAL-993 inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-b, cKit, and CSF-1R are also inhibited at higher concentrations (IC50's 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies. |
| Size | n/a |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide |
| Gene, Accession, CAS # | CAS: 269390-77-4 |
| Catalog # | LS-H14579 |
| Price | |
| Order / More Info | AAL-993 from LIFESPAN BIOSCIENCES INC. |
| Product Specific References | n/a |
| 產(chǎn)品資料 |
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