| Description | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. Interleukin-7 (IL-7) is a member of the interleukin family which regulates the development and survival of lymphoid and myeloid cells. It has a potent effect for the stimulation of the adaptative immune response, it promotes proliferation of lymphoid progenitors (Pre-B, Pro-B and early T cells), and the effects include mobilization, maturation, and maintenance of IL-7 responsive immune cells. The biological functions of IL-7 as a key lymphotrophin'' in JAK-STAT pathways, PI3 kinase pathway, and Src kinase pathway. IL-7 has also been shown to play a vital role in energy metabolism of T cells and regulating glucose uptake in T lymphocytes through Glut1 via activation of STAT5 and Akt. It has a thymic antiapoptotic effect, and induce the expression of antiapoptotic proteins Bcl-2 and Mcl-1 and the inhibition of preapoptotic proteins Bax and Bad. IL-7 has potential therapeutic applications for the lymphoid reconstitution of immuno-depressed patients (chemotherapy, radiation, AIDS, and bone marrow transplant). Recombinant human Interleukin 7 is a glycosylated polypeptide chain containing 160 amino acids (26 -177 of P13232 IL7_HUMAN ), fused to His tag at N-terminal. rHuman IL-7 migrate at approximately 18 - 25 kDa by SDS-PAGE. Purity >97% by SDS-PAGE gel |
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| Product Specific References | - T.J. Fry, C.L. Mackall, Interleukin-7: master regulator of peripheral T-cell homeostasis, Trends Immunol. 22 (2001) 564-571. - K.L. Komschlies, K.J. Grzegorzewski, R.H. Wiltrout, Diverse immunological and hematological effects of interleukin 7: implications for clinical application, J. Leukoc. Biol. 58 (1995) 623-633. - Q. Jiang, W.Q. Li, F.B. Aiello, R. Mazzucchelli, B. Asefa, A.R. Khaled, S.K. Durum, Cell biology of IL-7, a key lymphotrophin, Cytokine and Growth Factor Reviews16 (2005) 513-533. - J.A. Wofford, H.L. Wieman, S.R. Jacobs, Y. Zhao, J.C. Rathmell, IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T cell survival, Blood 111 (2008) 2101-2111. - J.H. Kim, J.E. Loveland, K.V. Sitz, S. Ratto Kim, R.J. McLinden, K. Tencer, K. Davis, D.S. Burke, R.N. Boswell, R.R. Redfield, D.L. Birx, Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1, Clinical and Experimental Immunology 108 (1997) 243-250. |
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