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產(chǎn)品名稱

CD180, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2083

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	CD180, Human
Clone	MHR73
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, FC, functional studies, IP, paraffin sections
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody MHR73 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. RP105 expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (MHR73) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing RP105 as a potent regulator of B-cell activation. In this context it is important to note that RP105 is associated with MD1, and that it mediates B-cell surface expression and LPS recognition and signalling in cooperation with TLR4. MD-1 seems to be requisite for efficient expression of RP105.
Immunogen	n/a
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HM2083
Price
Order / More Info	CD180, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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