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        產(chǎn)品名稱 CD180, Human Antibody from HYCULT BIOTECH
        產(chǎn)品貨號(hào) HM2084
        產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià),電話:010-67529703
        產(chǎn)品規(guī)格 50 μg
        產(chǎn)品品牌 HYCULT BIOTECH
        產(chǎn)品概述
        產(chǎn)品詳情
        Edit&nbsp
        Antigenic SpecificityCD180, Human
        CloneMHR73
        Host SpeciesMouse
        Reactive Specieshuman
        IsotypeIgG1
        Formatbiotin conjugate
        Size50 μg
        Concentration100 μg/ml
        Applicationsfrozen sections, FC
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionThe monoclonal antibody MHR73 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. RP105 expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (MHR73) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing RP105 as a potent regulator of B-cell activation. In this context it is important to note that RP105 is associated with MD1, and that it mediates B-cell surface expression and LPS recognition and signalling in cooperation with TLR4. MD-1 seems to be requisite for efficient expression of RP105.
        Immunogenn/a
        Other Namesn/a
        Gene, Accession #n/a
        Catalog #HM2084
        Price
        Order / More InfoCD180, Human Antibody from HYCULT BIOTECH
        Product Specific Referencesn/a
        產(chǎn)品資料
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