| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | C4d, Rat |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | rat |
|---|
| Isotype | n/a |
|---|
| Format | unconjugated |
|---|
| Size | 100 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | frozen sections, FC, paraffin sections, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The polyclonal antibody recognizes rat C4d. Complement factor C4 (MW 41 kDa), formerly known as Gg protein, consists of an alpha-, beta- and gamma-chain. The classical pathway of complement and the mannose binding lectin (MBL) activation pathway converge at C4. Activated, MASP-1 and MASP-2 cleave C4 resulting in the formation of C4a and C4b. The latter can be cleaved by factor I resulting in C4c and C4d, in which step all functional sites are lost. The C4d activation fragment of C4 is an excellent marker for classical complement pathway and MBL pathway activation. The thioester formed between the side chains of Cys1010 and Gln1013 within the C4d region of the α-chain mediates covalent attachment to the target surface bearing activated forms of C1s or MASP. Furthermore, C4d is highly homologous to C3d with over 35% shared amino acid sequence. In a number of diseases such as rheumatoid arthritis (RA), hereditary angioedema (HAE), systemic lupus erythematosus (SLE) and chronic urticaria with hypercomplementemia levels of C4d are significantly elevated in serum or plasma. C4d levels may also be elevated in plasma from patients with a variety of humoral autoimmune diseases in which complement activation is known to occur. Deposition of C4d in peritubular capillaries has been shown to be a sensitive marker for antibody-mediated (humoral) rejection in renal transplant biopsies. |
|---|
| Immunogen | A synthesized 14-mer peptide (STPAPRNPSEPVPQ) corresponding to amino acids 1223-1236 of rat C4, conjugated to keyhole limpet hemocyanin at the C-terminal part (for this a cysteine was added) |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HP8034 |
|---|
| Price | |
|---|
| Order / More Info | C4d, Rat Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
道日本一本草久,久久九九精品久久,中文字幕无码在线观看视频
|
超碰免费97,国产三级久久久久,99久久精品无免国产免费75
|
午夜影音,日日碰狠狠躁久久躁蜜桃,在线国产三级视频
|
八重神子的奖励免费观看,91精品欧美久久久久久久,欧美性爱免费在线视频
|
中文字幕 - 91爱爱,男人把女人到爽,玖玖玖在线
|
色欲亚洲,流着奶水的美丽少妇,国产性色
|
人人操天天摸,越南一级淫片在线观看,网红主播一级毛片
|
网友自拍色综合,国产刺激视频,黄片视频在线免费播放
|
亚洲精品AA,午夜视频啊啊啊,色情五月
|
偷拍视频免费在线观看,免费成人视频在线,成人精品一区日本无码网站45P
|
|